Scientist/Senior Scientist, Display Technologies
Company: BigHat Biosciences
Location: San Mateo
Posted on: February 16, 2026
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Job Description:
Job Description Job Description Description The Role: BigHat
Biosciences is seeking a self-motivated Scientist or Senior
Scientist to join the Display Technologies team. This individual
will expand BigHat’s ability to discover and engineer
next-generation antibodies and to generate high-quality data to
improve BigHat’s machine learning models using display
technologies. Key Responsibilities Conceive and lead R&D
projects to advance display technologies at BigHat. Design antibody
libraries to discover and optimize antibodies for affinity,
cross-reactivity, stability, and function across diverse formats
such as VHH, scFv, and Fab. Construct and QC phage and yeast
display libraries of diverse antibody formats to use for in vitro
selections (PCR, molecular cloning, electroporations). Perform
phage and yeast display selections using naive and affinity
maturation libraries to discover and/or engineer novel
next-generation antibodies for diverse therapeutic properties,
including co-selection for multiple key attributes Express, purify,
and characterize display-derived molecules using a suite of assays
including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
Analyze results from display selections to guide next steps and
future experiments. Collaborate with BigHat’s Data Science and
Machine Learning teams to facilitate data transfer and analysis to
further bolster library design and machine learning model training.
Present experimental plans and results during regular meetings with
manager and science teams. Skills Knowledge and Expertise PhD with
3 years of experience Extensive experience with phage and yeast
display workflows for antibody engineering. Experience with general
molecular biology tools (PCR, Molecular Cloning, Mutagenesis) and
developing/executing antibody binding assays. Effective time
management and excellent written and verbal communication skills
driving an ability to plan and deliver diverse technical projects
simultaneously in a dynamic start-up environment. Strong record
keeping skills using LIMS and electronic notebooks. Excited to work
with diverse, cross functional teams to onboard new assays and
disseminate results. Nice-to-haves include previous experience with
other display modalities (ribosome, mRNA, mammalian), NGS
prep/analysis of display campaigns, and experience using automation
for high-throughput assay development. Total Rewards The salary
estimated for this position is $145,000 - $187,000 bonus options
benefits. Compensation will vary depending on job-related
knowledge, skills, and experience. Actual compensation will be
confirmed in writing at the time of the offer.
Keywords: BigHat Biosciences, Vacaville , Scientist/Senior Scientist, Display Technologies, Engineering , San Mateo, California
